Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.33 |
| ▸ | TEAD1 | P28347 | 3/20 | 0.33 |
| ▸ | DPP4 | P27487 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | TET3 | O43151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.30 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.30 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.30 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.30 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.30 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20326344 | 0.82 | JAK3 (0.33) | JAK3TEAD1DPP4 | |
| SCHEMBL22969802 | 0.79 | JAK3 (0.36) | JAK3TEAD1 | |
| SCHEMBL24542941 | 0.79 | JAK3 (0.36) | JAK3TEAD1 | |
| SCHEMBL22970055 | 0.76 | JAK3 (0.34) | JAK3JAK2 | |
| SCHEMBL21186658 | 0.76 | JAK3 (0.34) | JAK3JAK2 | |
| SCHEMBL23664821 | 0.76 | JAK3 (0.34) | JAK3JAK2 | |
| SCHEMBL20334389 | 0.75 | DPP4 (0.36) | JAK3TEAD1DPP4 | |
| SCHEMBL24543192 | 0.74 | OPRK1 (0.34) | JAK3TEAD1 | |
| SCHEMBL22969760 | 0.74 | OPRK1 (0.34) | JAK3TEAD1 | |
| SCHEMBL28110995 | 0.72 | JAK3 (0.41) | JAK3DPP4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021023247-A1 | KRAS MUTANT PROTEIN INHIBITOR | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2021-02-11 | — | — | WO | disclosed |