Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 3/20 | 0.37 |
| ▸ | BTD | P43251 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23221969 | 0.83 | EGFR (0.41) | JAK3EGFRBTKJAK1MAP2K7 | |
| SCHEMBL18173568 | 0.79 | JAK3 (0.44) | JAK3EGFRBTKJAK1MAP2K7 | |
| SCHEMBL18173596 | 0.79 | JAK3 (0.44) | JAK3EGFRBTKJAK1MAP2K7 | |
| SCHEMBL28168621 | 0.79 | VNN1 (0.40) | VNN1BTDDPP4 | |
| SCHEMBL20456230 | 0.79 | TEAD1 (0.39) | JAK3BTKJAK1DPP4 | |
| SCHEMBL18478125 | 0.77 | ALDH1A1 (0.40) | VNN1BTDDPP4 | |
| SCHEMBL18478943 | 0.77 | ALDH1A1 (0.40) | VNN1BTDDPP4 | |
| SCHEMBL30208798 | 0.75 | CA12 (0.47) | JAK3EGFRBTKJAK1 | |
| SCHEMBL8362428 | 0.75 | CA12 (0.47) | JAK3EGFRBTKJAK1 | |
| SCHEMBL16802109 | 0.75 | CA12 (0.47) | JAK3EGFRBTKJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106061973-B | Pyrrolo [2,3-D ] pyrimidinyl, pyrrolo [2,3-B ] pyrazinyl and pyrrolo [2,3-D ] pyridylacrylamide | 辉瑞公司 | 2019-07-09 | — | — | CN | disclosed |
| CN-107417684-A | Heterocyclic acryloyloxy amine | 辉瑞公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-106061973-A | Pyrrolo [2,3-D ] pyrimidinyl, pyrrolo [2,3-B ] pyrazinyl and pyrrolo [2,3-D ] pyridylacrylamide | 辉瑞公司 | 2016-10-26 | — | — | CN | disclosed |