⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31166684 | 0.83 | KDM4C (0.32) | — | |
| SCHEMBL2849739 | 0.80 | KDM4C (0.41) | — | |
| SCHEMBL10062154 | 0.79 | L3MBTL1 (0.31) | — | |
| SCHEMBL22788816 | 0.77 | GRM4 (0.30) | — | |
| SCHEMBL22790562 | 0.77 | MAOA (0.34) | — | |
| SCHEMBL2852968 | 0.77 | ALOX15 (0.43) | — | |
| SCHEMBL1134031 | 0.76 | — | — | |
| SCHEMBL7086942 | 0.76 | ALOX15 (0.32) | — | |
| SCHEMBL28469015 | 0.75 | PAOX (0.31) | — | |
| Hydrochloric Acid SCHEMBL22987133 | 0.74 | KDM4C (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190144382-A1 | MEK Inhibitors and Methods of Their Use | EXELIXIS, INC. | 2019-05-16 | — | — | US | claimed |
| US-7999006-B2 | Anticancer agents; mitogen-activated protein kinases (MEK) | EXELIXIS, INC. (US) | 2011-08-16 | — | — | US | claimed |
| EP-1934174-A1 | AZETIDINES AS MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2008-06-25 | — | — | EP | claimed |
| WO-2007044515-A1 | AZETIDINES AS MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2007-04-19 | — | — | WO | claimed |
| EP-3277682-B1 | 6-MORPHOLINYL-2-PYRAZOLYL-9H-PURINE DERIVATIVES AND THEIR USE AS PI3K INHIBITORS | DAIICHI SANKYO CO LTD (JP) | 2019-04-24 | — | — | EP | disclosed |
| US-8552205-B2 | Derivatives of 6,7-dihydro-5H-imidazo[1,2-alpha]imidazole-3-carboxylic acid amides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-10-08 | — | — | US | disclosed |
| US-8354442-B2 | Imidazol-4-one and imidazole-4-thione compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2013-01-15 | — | — | US | disclosed |
| WO-2010062686-A2 | IMIDAZOL-4-ONE AND IMIDAZOLE-4-THIONE COMPOUNDS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2010-06-03 | — | — | WO | disclosed |
| US-20100113546-A1 | Imidazol-4-one and Imidazole-4-thione Compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2010-05-06 | — | — | US | disclosed |
| WO-2009070485-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-α]IMIDAZOLE-3- CARBOXYLIC ACID AMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-04 | — | — | WO | disclosed |
| EP-0796646-B1 | Method for the removal of carbon dioxide present in gases and absorbent | KANSAI ELECTRIC POWER CO (JP) | 2003-11-12 | — | — | EP | disclosed |
| US-5904908-A | USING AN AQUEOUS SOLUTION CONTAINING AN ALKYLAMINOAMIDE COMPOUND | MITSUBISHI HEAVY INDUSTRIES, LTD. (JP) | 1999-05-18 | — | — | US | disclosed |
| EP-0796646-A1 | Method for the removal of carbon dioxide present in gases and absorbent | THE KANSAI ELECTRIC POWER CO., INC. (JP) | 1997-09-24 | — | — | EP | disclosed |