Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2299406 | 0.81 | EPHX2 (0.33) | ALDH1A1TSHRTDP1 | |
| SCHEMBL2299229 | 0.75 | KDM4E (0.31) | — | |
| SCHEMBL2300241 | 0.75 | KDM4E (0.41) | ALDH1A1TSHRTDP1KMT2AHTT | |
| SCHEMBL2294529 | 0.74 | GLB1 (0.33) | ALDH1A1GBA1 | |
| SCHEMBL2295851 | 0.73 | CYP2C9 (0.38) | ALDH1A1KMT2A | |
| SCHEMBL2300211 | 0.73 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL2296528 | 0.73 | SIGMAR1 (0.33) | — | |
| SCHEMBL2300805 | 0.72 | KDM4E (0.34) | — | |
| SCHEMBL2300257 | 0.72 | DRD4 (0.53) | — | |
| SCHEMBL2299639 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999006-B2 | Anticancer agents; mitogen-activated protein kinases (MEK) | EXELIXIS, INC. (US) | 2011-08-16 | — | — | US | claimed |