Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.31 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.30 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | POLQ | O75417 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24697715 | 0.79 | KDM1A (0.36) | KDM1AKCNH2KDM1B | |
| SCHEMBL2964967 | 0.79 | HSP90AA1 (0.41) | KIF11HSP90AA1HSP90AB1IDO1NOTUM | |
| SCHEMBL19491471 | 0.78 | KIF11 (0.40) | KIF11HSP90AA1HSP90AB1PTPN7DUSP3 | |
| SCHEMBL856379 | 0.77 | KDM1A (0.39) | KDM1AKCNH2KDM1BUSP28 | |
| SCHEMBL16637281 | 0.77 | KIF11 (0.39) | KIF11PTPN7DUSP3ADRB2USP28 | |
| SCHEMBL2301196 | 0.77 | KIF11 (0.39) | KIF11HSP90AA1HSP90AB1IDO1KDM1A | |
| SCHEMBL1773032 | 0.75 | PTPN1 (0.37) | KDM1AKCNH2KDM1B | |
| SCHEMBL3873033 | 0.75 | KIF11 (0.47) | KIF11HSP90AA1HSP90AB1PTPN7DUSP3 | |
| SCHEMBL30574768 | 0.75 | PTPN1 (0.37) | KDM1AKCNH2KDM1B | |
| SCHEMBL4576842 | 0.74 | CYP11B1 (0.38) | KIF11PTPN7DUSP3KDM1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011103063-A1 | THERAPEUTIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-08-25 | — | — | WO | disclosed |