Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNK1 | Q9H4A3 | 4/20 | 0.72 |
| ▸ | LSS | P48449 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29719211 | 0.84 | WNK1 (1.00) | WNK1LSSCHRNA7STAT3MAPT | |
| SCHEMBL22972979 | 0.84 | WNK1 (1.00) | WNK1LSSCHRNA7STAT3MAPT | |
| Hydrochloric Acid SCHEMBL29719312 | 0.83 | WNK1 (0.98) | WNK1LSSCHRNA7STAT3MAPT | |
| Hydrochloric Acid SCHEMBL22972975 | 0.83 | WNK1 (0.98) | WNK1LSSCHRNA7STAT3MAPT | |
| SCHEMBL22972978 | 0.81 | WNK1 (1.00) | WNK1LSSCHRNA7STAT3PTGS2 | |
| SCHEMBL30423029 | 0.81 | WNK1 (1.00) | WNK1LSSCHRNA7STAT3PTGS2 | |
| SCHEMBL29719250 | 0.77 | WNK1 (0.64) | WNK1LSSSTAT3MAPTPTGS2 | |
| SCHEMBL22972976 | 0.74 | WNK1 (0.62) | WNK1LSSPTGS2POLBGPR183 | |
| SCHEMBL29719297 | 0.74 | WNK1 (0.62) | WNK1LSSPTGS2POLBGPR183 | |
| SCHEMBL29719242 | 0.64 | WNK1 (0.54) | WNK1LSSSTAT3MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4013413-A1 | TARGETING WNK1 IN BLOOD CANCERS | Københavns Universitet (DK) | 2022-06-22 | — | — | EP | disclosed |
| WO-2021028438-A1 | TARGETING WNK1 IN BLOOD CANCERS | Københavns Universitet (DK) | 2021-02-18 | — | — | WO | disclosed |
| EP-3777857-A1 | TARGETING WNK1 IN BLOOD CANCERS | Københavns Universitet (DK) | 2021-02-17 | — | — | EP | disclosed |