Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNK1 | Q9H4A3 | 5/20 | 1.00 |
| ▸ | LSS | P48449 | 2/20 | 0.41 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29719211 | 1.00 | WNK1 (1.00) | WNK1LSSSLC12A2STAT3PTGS2 | |
| Hydrochloric Acid SCHEMBL29719312 | 0.99 | WNK1 (0.98) | WNK1LSSSLC12A2STAT3PTGS2 | |
| Hydrochloric Acid SCHEMBL22972975 | 0.99 | WNK1 (0.98) | WNK1LSSSLC12A2STAT3PTGS2 | |
| SCHEMBL22972978 | 0.94 | WNK1 (1.00) | WNK1LSSSLC12A2STAT3PTGS2 | |
| SCHEMBL30423029 | 0.94 | WNK1 (1.00) | WNK1LSSSLC12A2STAT3PTGS2 | |
| SCHEMBL22972977 | 0.84 | WNK1 (0.72) | WNK1LSSSTAT3PTGS2GPR183 | |
| SCHEMBL29719250 | 0.78 | WNK1 (0.64) | WNK1LSSSTAT3PTGS2POLB | |
| SCHEMBL22972976 | 0.75 | WNK1 (0.62) | WNK1LSSPTGS2GPR183POLB | |
| SCHEMBL29719297 | 0.75 | WNK1 (0.62) | WNK1LSSPTGS2GPR183POLB | |
| SCHEMBL22972973 | 0.71 | WNK1 (0.57) | WNK1LSSPTGS2GPR183TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12458637-B2 | Targeting WNK1 in blood cancers | Københavns Universitet (DK) | 2025-11-04 | — | — | US | claimed |
| US-12458637-B2 | Targeting WNK1 in blood cancers | Københavns Universitet (DK) | 2025-11-04 | — | — | US | disclosed |
| EP-4013413-B1 | TARGETING WNK1 IN BLOOD CANCERS | UNIV COPENHAGEN (DK) | 2025-01-29 | — | — | EP | disclosed |
| US-20220288063-A1 | TARGETING WNK1 IN BLOOD CANCERS | Københavns Universitet (DK) | 2022-09-15 | — | — | US | disclosed |
| EP-4013413-A1 | TARGETING WNK1 IN BLOOD CANCERS | Københavns Universitet (DK) | 2022-06-22 | — | — | EP | disclosed |
| WO-2021028438-A1 | TARGETING WNK1 IN BLOOD CANCERS | Københavns Universitet (DK) | 2021-02-18 | — | — | WO | disclosed |
| EP-3777857-A1 | TARGETING WNK1 IN BLOOD CANCERS | Københavns Universitet (DK) | 2021-02-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220288063-A1 | TARGETING WNK1 IN BLOOD CANCERS | WNK1, WNK2, TTK | WNK1 1/4885LSS 4376/4885SLC12A2 2391/4885 |
| US-12458637-B2 | Targeting WNK1 in blood cancers | WNK1, WNK2, TTK | WNK1 1/4885LSS 4376/4885SLC12A2 2391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.