Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNK1 | Q9H4A3 | 2/20 | 0.62 |
| ▸ | GPR183 | P32249 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | LSS | P48449 | 3/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TACR3 | P29371 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29719297 | 1.00 | WNK1 (0.62) | WNK1GPR183MEN1KMT2AATM | |
| SCHEMBL30423029 | 0.78 | WNK1 (1.00) | WNK1GPR183TP53LSSPTGS2 | |
| SCHEMBL22972978 | 0.78 | WNK1 (1.00) | WNK1GPR183TP53LSSPTGS2 | |
| SCHEMBL22972979 | 0.75 | WNK1 (1.00) | WNK1GPR183TP53LSSPTGS2 | |
| SCHEMBL29719211 | 0.75 | WNK1 (1.00) | WNK1GPR183TP53LSSPTGS2 | |
| Hydrochloric Acid SCHEMBL22972975 | 0.75 | WNK1 (0.98) | WNK1GPR183TP53LSSPTGS2 | |
| Hydrochloric Acid SCHEMBL29719312 | 0.75 | WNK1 (0.98) | WNK1GPR183TP53LSSPTGS2 | |
| SCHEMBL5544496 | 0.75 | AKR1C3 (0.65) | GPR183MEN1KMT2AATMTP53 | |
| SCHEMBL30065590 | 0.74 | GPR183 (0.55) | GPR183TP53LSSPTGS2AKR1C3 | |
| SCHEMBL22972977 | 0.74 | WNK1 (0.72) | WNK1GPR183MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12458637-B2 | Targeting WNK1 in blood cancers | Københavns Universitet (DK) | 2025-11-04 | — | — | US | disclosed |
| EP-4013413-B1 | TARGETING WNK1 IN BLOOD CANCERS | UNIV COPENHAGEN (DK) | 2025-01-29 | — | — | EP | disclosed |
| US-20220288063-A1 | TARGETING WNK1 IN BLOOD CANCERS | Københavns Universitet (DK) | 2022-09-15 | — | — | US | disclosed |
| EP-4013413-A1 | TARGETING WNK1 IN BLOOD CANCERS | Københavns Universitet (DK) | 2022-06-22 | — | — | EP | disclosed |
| WO-2021028438-A1 | TARGETING WNK1 IN BLOOD CANCERS | Københavns Universitet (DK) | 2021-02-18 | — | — | WO | disclosed |
| EP-3777857-A1 | TARGETING WNK1 IN BLOOD CANCERS | Københavns Universitet (DK) | 2021-02-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220288063-A1 | TARGETING WNK1 IN BLOOD CANCERS | WNK1, WNK2, TTK | WNK1 1/4885GPR183 1921/4885MEN1 425/4885 |
| US-12458637-B2 | Targeting WNK1 in blood cancers | WNK1, WNK2, TTK | WNK1 1/4885GPR183 1921/4885MEN1 425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.