Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29380769 | 0.81 | MAPT (0.57) | MAPTNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL416462 | 0.81 | MAPT (0.57) | MAPTNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL30594479 | 0.81 | ALDH1A1 (0.48) | MAPTSMN1; SMN2L3MBTL1LMNAHPGD | |
| SCHEMBL872421 | 0.80 | HTR1A (0.61) | MAPTNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL5810886 | 0.78 | NPC1 (0.41) | MAPTNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL3269301 | 0.78 | MAPT (0.59) | MAPTNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL6203294 | 0.77 | MAOB (0.51) | MAPTNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL3959610 | 0.77 | MAOB (0.51) | CCNB2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL30594481 | 0.77 | SLC2A1 (0.54) | MAPTSMN1; SMN2LMNAHTTMAOA | |
| SCHEMBL5722854 | 0.77 | MAPT (0.59) | MAPTNPC1RAB9ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774777-A2 | MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |