Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CBFB | Q13951 | 2/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | P4HB | P07237 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19344365 | 1.00 | PIK3CD (0.45) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL19344352 | 0.80 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL19344362 | 0.79 | PIK3CD (0.32) | PIK3CD | |
| SCHEMBL29869127 | 0.79 | PIK3CD (0.32) | PIK3CD | |
| SCHEMBL22476054 | 0.78 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL19344351 | 0.78 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL28685388 | 0.74 | MET (0.40) | — | |
| SCHEMBL28685387 | 0.74 | MET (0.40) | — | |
| SCHEMBL31037116 | 0.74 | MET (0.40) | — | |
| SCHEMBL28685390 | 0.74 | MET (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11446301-B2 | Quinoline analogs as phosphatidylinositol 3-kinase inhibitors | NANJING ZHENGXIANG PHARMACEUTICALS CO., LTD. (CN) | 2022-09-20 | — | — | US | disclosed |
| US-20210046075-A1 | QUINOLINE ANALOGS AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | NANJING ZHENGXIANG PHARMACEUTICALS CO., LTD. (CN) | 2021-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11446301-B2 | Quinoline analogs as phosphatidylinositol 3-kinase inhibitors | PIK3CD, PI4KB, PIK3CA | PIK3CD 1/4885PIK3CA 3/4885PIK3CB 9/4885 |
| US-20210046075-A1 | QUINOLINE ANALOGS AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PIK3CD, PI4KB, PIK3CA | PIK3CD 1/4885PIK3CA 3/4885PIK3CB 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.