Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 1.00 |
| ▸ | CDK8 | P49336 | 7/20 | 0.70 |
| ▸ | AXL | P30530 | 2/20 | 0.70 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.68 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.59 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.59 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | PLK4 | O00444 | 2/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.57 |
| ▸ | INSR | P06213 | 2/20 | 0.57 |
| ▸ | CDK1 | P06493 | 2/20 | 0.57 |
| ▸ | ROS1 | P08922 | 2/20 | 0.57 |
| ▸ | FER | P16591 | 2/20 | 0.57 |
| ▸ | CDK2 | P24941 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4831501 | 0.87 | CDK8 (0.81) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL12127266 | 0.83 | RIPK1 (0.71) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL16746926 | 0.83 | RIPK1 (0.71) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL413503 | 0.83 | RIPK1 (0.71) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL410298 | 0.83 | RIPK1 (0.71) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL15871324 | 0.83 | RIPK1 (0.71) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL410704 | 0.82 | CDK8 (1.00) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL31064962 | 0.82 | RIPK1 (0.69) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL4165829 | 0.82 | RIPK1 (0.69) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL416750 | 0.81 | PIK3CA (1.00) | RIPK1CDK8AXLPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118344359-A | RIPK1 kinase targeted inhibitor and application thereof | 中国药科大学 | 2024-07-16 | — | — | CN | disclosed |
| WO-2018233526-A9 | CSF1R INHIBITOR, AND MANUFACTURING METHOD THEREFOR AND APPLICATION THEREOF | 上海和誉生物医药科技有限公司 | 2021-02-18 | — | — | WO | disclosed |
| CN-110198941-A | Pyrrolopyridine N- oxidized derivatives and its preparation method and application | 江苏豪森药业集团有限公司 | 2019-09-03 | — | — | CN | disclosed |
| CN-105431422-B | Isoindoline or isoquinoline compounds, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2019-08-30 | — | — | CN | disclosed |
| CN-109456324-A | New isoindoline or isoquinoline compound, preparation method and the Pharmaceutical composition containing them | 法国施维雅药厂 | 2019-03-12 | — | — | CN | disclosed |
| CN-105431422-A | Isoindoline or isoquinoline compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB | 2016-03-23 | — | — | CN | disclosed |