Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.71 |
| ▸ | CDK8 | P49336 | 9/20 | 0.70 |
| ▸ | AXL | P30530 | 2/20 | 0.70 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.68 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.68 |
| ▸ | PLK4 | O00444 | 2/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.57 |
| ▸ | INSR | P06213 | 2/20 | 0.57 |
| ▸ | CDK1 | P06493 | 2/20 | 0.57 |
| ▸ | ROS1 | P08922 | 2/20 | 0.57 |
| ▸ | FER | P16591 | 2/20 | 0.57 |
| ▸ | CDK2 | P24941 | 2/20 | 0.57 |
| ▸ | MARK3 | P27448 | 2/20 | 0.57 |
| ▸ | FLT4 | P35916 | 2/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.57 |
| ▸ | SYK | P43405 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4831501 | 0.87 | CDK8 (0.81) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL4294342 | 0.83 | PIK3CA (0.64) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL413503 | 0.83 | RIPK1 (0.71) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL16746926 | 0.83 | RIPK1 (0.71) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL410298 | 0.83 | RIPK1 (0.71) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL22978455 | 0.83 | RIPK1 (1.00) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL15871324 | 0.83 | RIPK1 (0.71) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL410704 | 0.82 | CDK8 (1.00) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL857125 | 0.82 | CDK8 (0.69) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL416750 | 0.81 | PIK3CA (1.00) | RIPK1CDK8AXLPIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116768886-A | N- (4- (1H-pyrrolo [2,3-b ] pyridin-5-yl) phenyl) amide derivatives, preparation and use thereof | 安徽医科大学 | 2023-09-19 | — | — | CN | claimed |
| CN-116768886-B | N- (4- (1H-pyrrolo [2,3-b ] pyridin-5-yl) phenyl) amide derivatives, preparation and use thereof | 安徽医科大学 | 2025-09-16 | — | — | CN | disclosed |
| CN-116768886-B | N- (4- (1H-pyrrolo [2,3-b ] pyridin-5-yl) phenyl) amide derivatives, preparation and use thereof | 安徽医科大学 | 2025-09-16 | — | — | CN | disclosed |
| CN-116768886-A | N- (4- (1H-pyrrolo [2,3-b ] pyridin-5-yl) phenyl) amide derivatives, preparation and use thereof | 安徽医科大学 | 2023-09-19 | — | — | CN | disclosed |
| CN-116768886-A | N- (4- (1H-pyrrolo [2,3-b ] pyridin-5-yl) phenyl) amide derivatives, preparation and use thereof | 安徽医科大学 | 2023-09-19 | — | — | CN | disclosed |
| CN-116768886-A | N- (4- (1H-pyrrolo [2,3-b ] pyridin-5-yl) phenyl) amide derivatives, preparation and use thereof | 安徽医科大学 | 2023-09-19 | — | — | CN | disclosed |
| US-20110282056-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2011-11-17 | — | — | US | disclosed |
| WO-2009094123-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK SERONO S.A. (CH) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110282056-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MAP3K19, MAP3K20, MAP3K1 | RIPK1 417/4885CDK8 239/4885AXL 383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.