Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | DAGLA | Q9Y4D2 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ABHD11 | Q8NFV4 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14646609 | 0.77 | NPC1 (0.60) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL13198885 | 0.77 | NPC1 (0.60) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL5697162 | 0.75 | ALDH1A1 (0.63) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL31106406 | 0.74 | NPC1 (0.60) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL7918528 | 0.73 | HCRTR2 (0.49) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL7918530 | 0.73 | HCRTR2 (0.49) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL809534 | 0.73 | PREP (0.57) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL14578664 | 0.72 | HPGD (0.76) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL13198897 | 0.72 | KMT2A (0.51) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL21057416 | 0.72 | KDM4E (0.52) | NPC1RAB9AHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021026803-A1 | PIPERIDINYL-METHYL-PURINEAMINES AS NSD2 INHIBITORS AND ANTI-CANCER AGENTS | NOVARTIS AG (CH) | 2021-02-18 | — | — | WO | disclosed |