Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22980192 | 1.00 | LMNA (0.33) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL29032631 | 0.81 | LMNA (0.33) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL28635010 | 0.81 | AOC1 (0.31) | — | |
| SCHEMBL29032630 | 0.81 | LMNA (0.33) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5165702 | 0.73 | CA2 (0.42) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL24372220 | 0.73 | LMNA (0.39) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL29210106 | 0.71 | LMNA (0.52) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL23629921 | 0.70 | LMNA (0.32) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL31314516 | 0.69 | LMNA (0.32) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL16330481 | 0.69 | LMNA (0.36) | LMNACHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021115401-A1 | FLUORINE-CONTAINING HETEROCYCLIC DERIVATIVES WITH MACROCYCLIC STRUCTURE AND USE THEREOF | 成都倍特药业股份有限公司 | 2021-06-17 | — | — | WO | disclosed |
| WO-2021042890-A1 | HETEROCYCLIC COMPOUND AND APPLICATION THEREOF AS TRK KINASE INHIBITOR | 罗欣药业(上海)有限公司 | 2021-03-11 | — | — | WO | disclosed |
| WO-2021027503-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND INTERMEDIATE AND USE THEREOF | 罗欣药业(上海)有限公司 | 2021-02-18 | — | — | WO | disclosed |