Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.34 |
| ▸ | PPM1D | O15297 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | PPP5C | P53041 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9754728 | 0.87 | MEN1 (0.31) | GBA2L3MBTL1 | |
| SCHEMBL9596202 | 0.84 | GBA2 (0.32) | GBA2LMNAPOLBSMN1; SMN2 | |
| SCHEMBL9595806 | 0.84 | GBA2 (0.36) | GBA2LMNAPOLBSMN1; SMN2ECE1 | |
| SCHEMBL4078697 | 0.84 | GBA2 (0.41) | GBA2LMNAPOLBSMN1; SMN2ECE1 | |
| SCHEMBL9595393 | 0.82 | GBA2 (0.35) | GBA2LMNAPOLBSMN1; SMN2ECE1 | |
| SCHEMBL8113961 | 0.82 | GBA2 (0.35) | GBA2LMNAPOLBSMN1; SMN2ECE1 | |
| SCHEMBL9384319 | 0.81 | CYP19A1 (0.33) | PPM1D | |
| SCHEMBL2146097 | 0.81 | GBA2 (0.41) | GBA2LMNAPOLBSMN1; SMN2ECE1 | |
| SCHEMBL30104016 | 0.81 | TSHR (0.37) | PPM1D | |
| SCHEMBL9595391 | 0.81 | LMNA (0.36) | GBA2LMNAPOLBSMN1; SMN2ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023041757-A1 | NEW COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2023-03-23 | — | — | WO | disclosed |
| WO-2023041756-A1 | NEW COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2023-03-23 | — | — | WO | disclosed |
| EP-4010080-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | Artios Pharma Limited (GB) | 2022-06-15 | — | — | EP | disclosed |
| WO-2021028643-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |