Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 10/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 10/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 7/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 6/20 | 0.35 |
| ▸ | CDK1 | P06493 | 6/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.35 |
| ▸ | PRKACA | P17612 | 5/20 | 0.35 |
| ▸ | PRKACG | P22612 | 5/20 | 0.35 |
| ▸ | PRKACB | P22694 | 5/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 5/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14157267 | 0.72 | NPC1 (0.47) | CYP1A2KMT2AMAPK1 | |
| SCHEMBL29079328 | 0.69 | NISCH (0.47) | IDO1CSNK1A1MEN1KMT2AMAPK1 | |
| SCHEMBL6907831 | 0.65 | NISCH (0.42) | IDO1CSNK1A1CYP1A2MEN1KMT2A | |
| SCHEMBL5491437 | 0.65 | — | — | |
| SCHEMBL1954237 | 0.65 | MTOR (0.42) | CDK2CYP1A2CCNE1MEN1KMT2A | |
| SCHEMBL25219870 | 0.64 | — | — | |
| SCHEMBL755641 | 0.64 | IMPDH2 (0.39) | CDK5CDK5R1CCNT1CDK9GSK3B | |
| SCHEMBL29754089 | 0.63 | IMPDH2 (0.38) | CDK5CDK5R1CCNT1CDK9GSK3B | |
| SCHEMBL6199596 | 0.63 | SMN1; SMN2 (0.41) | GSK3BCSNK1A1CSNK1DCYP1A2MAPK9 | |
| SCHEMBL197279 | 0.62 | NISCH (0.54) | IDO1CSNK1A1CYP1A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109900-A1 | AZABICYCLIC SHP2 INHIBITORS | PROMIDIS S.R.L. (IT) | 2024-04-04 | — | — | US | disclosed |
| US-20220289753-A1 | SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2022-09-15 | — | — | US | disclosed |
| WO-2022167682-A1 | AZABICYCLIC SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2022-08-11 | — | — | WO | disclosed |
| EP-4039685-A1 | AZABICYCLIC SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2022-08-10 | — | — | EP | disclosed |
| CN-114728935-A | SHP2 inhibitor | IRBM股份公司 | 2022-07-08 | — | — | CN | disclosed |
| EP-4010335-A1 | SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2022-06-15 | — | — | EP | disclosed |
| WO-2021028362-A1 | SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2021-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240109900-A1 | AZABICYCLIC SHP2 INHIBITORS | PTPN22, PTPN2, PTPN5 | CDK5 899/4885CDK5R1 1081/4885CDK2 605/4885 |
| US-20220289753-A1 | SHP2 INHIBITORS | PTPN1, PTPN2, PTPN7 | CDK5 1421/4885CDK5R1 1799/4885CDK2 802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.