Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.35 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15554512 | 0.83 | DPP4 (0.39) | PDPK1PYCR1KDM1ADGAT1KDM1B | |
| SCHEMBL1819663 | 0.83 | TAAR1 (0.50) | PDPK1PYCR1KDM1ANPC1RAB9A | |
| SCHEMBL29393338 | 0.82 | PYCR1 (0.47) | PDPK1PYCR1KDM1ANPC1RAB9A | |
| SCHEMBL308050 | 0.82 | PYCR1 (0.47) | PDPK1PYCR1KDM1ANPC1RAB9A | |
| SCHEMBL20465750 | 0.82 | PYCR1 (0.47) | PDPK1PYCR1KDM1ANPC1RAB9A | |
| SCHEMBL1311178 | 0.81 | PDPK1 (0.44) | PDPK1PYCR1KDM1ANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL12476650 | 0.81 | TAAR1 (0.48) | PDPK1PYCR1KDM1ANPC1RAB9A | |
| SCHEMBL5879 | 0.81 | PDPK1 (0.44) | PDPK1PYCR1KDM1ANPC1RAB9A | |
| SCHEMBL5404668 | 0.81 | PYCR1 (0.47) | PDPK1PYCR1KDM1ANPC1RAB9A | |
| SCHEMBL5826 | 0.81 | PDPK1 (0.48) | PDPK1PYCR1KDM1ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107074768-B | Pyridone derivatives as inhibitors of transfection Rearrangement (RET) kinase | 葛兰素史克知识产权发展有限公司 | 2019-12-10 | — | — | CN | disclosed |
| EP-2744333-A1 | FATTY ACID SYNTHASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2014-06-25 | — | — | EP | disclosed |
| CN-101006092-B | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and therapeutic agents using the same | PFIZER | 2013-04-17 | — | — | CN | disclosed |
| WO-2013028447-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |
| CN-101351451-B | Polycyclic amino acid derivatives and methods of use thereof | LEXICON PHARMACEUTICALS INC | 2013-02-20 | — | — | CN | disclosed |
| CN-102753558-A | Nitroimidazooxazines and their use in antitubercular therapy | GLOBAL ALLIANCE FOR TB DRUG DEV | 2012-10-24 | — | — | CN | disclosed |
| CN-102666541-A | Purine or deazapurine derivatives for the treatment of, in particular, viral infections | GILEAD SCIENCES INC | 2012-09-12 | — | — | CN | disclosed |
| CN-102361862-A | Thiophenyl sulfonamides for the treatment of alzheimer's disease | BRISTOL MYERS SQUIBB CO | 2012-02-22 | — | — | CN | disclosed |
| WO-2011103063-A1 | THERAPEUTIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-08-25 | — | — | WO | disclosed |
| CN-101538268-B | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same | PFIZER | 2011-07-27 | — | — | CN | disclosed |
| CN-102066337-A | 5-hydroxypyrimidine-4-carboxamide compounds | DAIICHI SANKYO CO LTD | 2011-05-18 | — | — | CN | disclosed |
| CN-101918392-A | Pyrazole derivatives as 5-LO inhibitors | PFIZER | 2010-12-15 | — | — | CN | disclosed |
| CN-101538268-A | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same | PFIZER | 2009-09-23 | — | — | CN | disclosed |
| CN-101006092-A | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and therapeutic agents using the same | PFIZER (US) | 2007-07-25 | — | — | CN | disclosed |