Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.52 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TYR | P14679 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16736848 | 0.83 | ALOX15 (0.52) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL9503098 | 0.82 | ALDH1A1 (0.71) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL10907968 | 0.82 | ALDH1A1 (0.56) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL23542362 | 0.81 | ALOX15 (0.62) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL12162725 | 0.81 | SMN1; SMN2 (0.44) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL627857 | 0.79 | ALOX15 (0.75) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL29414126 | 0.79 | ALOX15 (0.75) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL931843 | 0.79 | ALOX15 (0.59) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL23811949 | 0.79 | SMN1; SMN2 (0.38) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL13145524 | 0.79 | CD44 (0.42) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10919850-B2 | Covalent inhibitors of KRas G12C | ARAXES PHARMA LLC (US) | 2021-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10919850-B2 | Covalent inhibitors of KRas G12C | KRAS, NRAS, HRAS | ALDH1A1 2706/4885ALOX15 4571/4885SMN1; SMN2 3761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.