Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.56 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 7/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | TYR | P14679 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10938794 | 0.91 | TSHR (0.52) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL9503098 | 0.86 | ALDH1A1 (0.71) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL16736702 | 0.86 | ALOX15 (0.71) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL22984907 | 0.82 | ALDH1A1 (0.52) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL16736848 | 0.82 | ALOX15 (0.52) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL13911912 | 0.82 | ALDH1A1 (0.41) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL4126691 | 0.81 | ALOX15 (0.64) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL814392 | 0.80 | ALDH1A1 (0.50) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL12733032 | 0.79 | SMN1; SMN2 (0.42) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL31497679 | 0.79 | SMN1; SMN2 (0.45) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10919850-B2 | Covalent inhibitors of KRas G12C | ARAXES PHARMA LLC (US) | 2021-02-16 | — | — | US | disclosed |
| US-20190262342-A1 | COMBINATION THERAPIES FOR TREATMENT OF CANCER | ARAXES PHARMA LLC | 2019-08-29 | — | — | US | disclosed |
| US-9926267-B2 | Covalent inhibitors of K-Ras G12C | ARAXES PHARMA LLC (US) | 2018-03-27 | — | — | US | disclosed |
| US-20160166571-A1 | COMBINATION THERAPIES FOR TREATMENT OF CANCER | ARAXES PHARMA LLC | 2016-06-16 | — | — | US | disclosed |
| US-9227978-B2 | Covalent inhibitors of Kras G12C | ARAXES PHARMA LLC (US) | 2016-01-05 | — | — | US | disclosed |
| US-20140288045-A1 | COVALENT INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC | 2014-09-25 | — | — | US | disclosed |
| US-4588835-A | Process for preparing alkoxyphenols | OTSUKA KAGAKU YAKUHIN KABUSHIKI KAISHA (JP) | 1986-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288045-A1 | COVALENT INHIBITORS OF KRAS G12C | KRAS, NRAS, HRAS | ALDH1A1 2706/4885ALOX15 4571/4885SMN1; SMN2 3761/4885 |
| US-20190262342-A1 | COMBINATION THERAPIES FOR TREATMENT OF CANCER | KRAS, TP53, HRAS | ALDH1A1 1577/4885ALOX15 4380/4885SMN1; SMN2 3583/4885 |
| US-10919850-B2 | Covalent inhibitors of KRas G12C | KRAS, NRAS, HRAS | ALDH1A1 2706/4885ALOX15 4571/4885SMN1; SMN2 3761/4885 |
| US-20160166571-A1 | COMBINATION THERAPIES FOR TREATMENT OF CANCER | KRAS, TP53, HRAS | ALDH1A1 1577/4885ALOX15 4380/4885SMN1; SMN2 3583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.