Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 9/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | PDE9A | O76083 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13720815 | 0.82 | ACACB (0.49) | KMT2AMEN1NAAAACACBHTR2C | |
| SCHEMBL20306371 | 0.78 | ACACB (0.51) | KMT2AMEN1ACACBNPSR1HRH3 | |
| SCHEMBL12160713 | 0.78 | ACACB (0.51) | KMT2AMEN1ACACBALDH1A1NPSR1 | |
| SCHEMBL3125920 | 0.78 | ACHE (0.41) | KMT2AMEN1NAAAALDH1A1 | |
| SCHEMBL2302743 | 0.78 | SLC6A4 (0.52) | KMT2AMEN1RAB9A | |
| SCHEMBL2299147 | 0.78 | CA1 (0.48) | KMT2AMEN1RAB9AALDH1A1NPSR1 | |
| SCHEMBL13439687 | 0.77 | NPSR1 (0.51) | KMT2AMEN1ACACBHPGDALDH1A1 | |
| SCHEMBL29152373 | 0.77 | NPSR1 (0.51) | KMT2AMEN1ACACBHPGDALDH1A1 | |
| SCHEMBL14312218 | 0.77 | SLC6A4 (0.53) | ACACBHTR2CHTR2B | |
| SCHEMBL30212205 | 0.76 | NAAA (0.42) | KMT2AMEN1NAAAACACBHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536689-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | Amgen Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103196-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | AMGEN INC. (US) | 2011-08-25 | — | — | WO | disclosed |