Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 4/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14342873 | 0.92 | GPR183 (0.44) | KITKMT2ARAB9ANPC1KCNK3 | |
| SCHEMBL2298545 | 0.83 | FPR2 (0.54) | KMT2ARAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2298347 | 0.78 | KMT2A (0.51) | KMT2ARAB9ANPC1LMNAMEN1 | |
| SCHEMBL14720196 | 0.77 | HDAC2 (0.46) | RAB9ANPC1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL14151538 | 0.75 | KMT2A (0.50) | KMT2ARAB9ANPC1MEN1KDM4E | |
| SCHEMBL2295438 | 0.73 | KMT2A (0.48) | KMT2ARAB9ANPC1LMNAMEN1 | |
| SCHEMBL2299286 | 0.73 | KMT2A (0.48) | KMT2ARAB9ANPC1LMNAMEN1 | |
| SCHEMBL14152796 | 0.73 | KMT2A (0.48) | KMT2ARAB9ANPC1LMNAMEN1 | |
| SCHEMBL2300230 | 0.72 | HDAC2 (0.39) | KITKMT2ARAB9AKCNK3KCNK9 | |
| SCHEMBL3042748 | 0.69 | SMN1; SMN2 (0.60) | KMT2ARAB9ASMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2538787-A1 | TRIAZOLONES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011103546-A1 | TRIAZOLONES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-08-25 | — | — | WO | disclosed |