Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 12/20 | 0.48 |
| ▸ | IGF1R | P08069 | 10/20 | 0.48 |
| ▸ | INSR | P06213 | 9/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 2/20 | 0.47 |
| ▸ | GAK | O14976 | 2/20 | 0.47 |
| ▸ | ERN1 | O75460 | 2/20 | 0.47 |
| ▸ | STK10 | O94804 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 2/20 | 0.47 |
| ▸ | FES | P07332 | 2/20 | 0.47 |
| ▸ | YES1 | P07947 | 2/20 | 0.47 |
| ▸ | HCK | P08631 | 2/20 | 0.47 |
| ▸ | ROS1 | P08922 | 2/20 | 0.47 |
| ▸ | FER | P16591 | 2/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22985901 | 0.83 | EGFR (0.41) | EGFRALKIGF1RINSRTNK2 | |
| SCHEMBL19921199 | 0.81 | ALK (0.49) | EGFRALKIGF1RINSRMAP3K7 | |
| SCHEMBL22985878 | 0.81 | FES (0.61) | EGFRALKIGF1RINSRMAP3K7 | |
| SCHEMBL21183052 | 0.78 | ALK (0.55) | EGFRALKIGF1RINSRABL1 | |
| SCHEMBL26270561 | 0.77 | ALK (0.73) | EGFRALKIGF1RINSRMAP3K7 | |
| SCHEMBL18637132 | 0.77 | ALK (0.81) | EGFRALKIGF1RINSRMAP3K7 | |
| SCHEMBL21099658 | 0.77 | ALK (0.60) | EGFRALKIGF1RINSRMAP3K7 | |
| SCHEMBL19921194 | 0.76 | ALK (0.59) | EGFRALKIGF1RINSRMAP3K7 | |
| SCHEMBL22985890 | 0.76 | FES (0.60) | EGFRALKIGF1RINSRMAP3K7 | |
| SCHEMBL21099501 | 0.75 | ALK (0.52) | EGFRALKIGF1RINSRMAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |