Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 18/20 | 0.63 |
| ▸ | INSR | P06213 | 15/20 | 0.63 |
| ▸ | IGF1R | P08069 | 15/20 | 0.63 |
| ▸ | EGFR | P00533 | 3/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | STK10 | O94804 | 1/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.57 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | CD74 | P04233 | 1/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | FES | P07332 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.57 |
| ▸ | YES1 | P07947 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22985929 | 0.90 | TTK (0.57) | ALKINSRIGF1RFESFLT3 | |
| SCHEMBL18018887 | 0.89 | ALK (0.76) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL4767413 | 0.84 | TTK (0.66) | ALKINSRIGF1RPTK2 | |
| SCHEMBL21099421 | 0.83 | ALK (0.63) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL22985902 | 0.83 | TTK (0.54) | ALKINSRIGF1RFESFGFR1 | |
| SCHEMBL24327559 | 0.83 | ALK (0.60) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL19921137 | 0.82 | ALK (0.62) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL3131543 | 0.81 | TTK (0.64) | ALKINSRIGF1RPTK2 | |
| SCHEMBL18018897 | 0.80 | ALK (0.63) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL22985895 | 0.79 | ALK (0.45) | ALKINSRIGF1REGFRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3778604-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |