Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 7/20 | 0.57 |
| ▸ | IGF1R | P08069 | 7/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.54 |
| ▸ | INSR | P06213 | 6/20 | 0.54 |
| ▸ | FES | P07332 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.51 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22985902 | 0.93 | TTK (0.54) | TTKIGF1RALKINSRFES | |
| SCHEMBL22985880 | 0.90 | ALK (0.63) | IGF1RALKINSRFESFLT3 | |
| SCHEMBL18018865 | 0.87 | TTK (0.68) | TTKIGF1RALKINSRFES | |
| SCHEMBL22985875 | 0.85 | TTK (0.51) | TTKIGF1RALKINSRFES | |
| SCHEMBL18018796 | 0.84 | TTK (0.80) | TTKIGF1RALKINSRFES | |
| SCHEMBL22985895 | 0.83 | ALK (0.45) | TTKIGF1RALKINSRFES | |
| SCHEMBL4768288 | 0.81 | TTK (0.62) | TTKALKINSRPTK2 | |
| SCHEMBL18018886 | 0.80 | TTK (0.63) | TTKIGF1RALKINSRFES | |
| SCHEMBL18018913 | 0.80 | EGFR (0.51) | TTKIGF1RALKINSRFES | |
| SCHEMBL18018892 | 0.80 | TTK (0.50) | TTKIGF1RALKINSRFES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3778604-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |