Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 9/20 | 0.45 |
| ▸ | TTK | P33981 | 5/20 | 0.44 |
| ▸ | IGF1R | P08069 | 4/20 | 0.43 |
| ▸ | INSR | P06213 | 3/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.43 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | FES | P07332 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | ROS1 | P08922 | 1/20 | 0.40 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22985902 | 0.90 | TTK (0.54) | ALKTTKIGF1RINSRFGFR1 | |
| SCHEMBL18018899 | 0.89 | ALK (0.53) | ALKTTKIGF1RINSRFGFR1 | |
| SCHEMBL22985875 | 0.83 | TTK (0.51) | ALKTTKIGF1RINSRFGFR1 | |
| SCHEMBL22985929 | 0.83 | TTK (0.57) | ALKTTKIGF1RINSRDCLK1 | |
| SCHEMBL22985880 | 0.79 | ALK (0.63) | ALKIGF1RINSRFGFR1FGFR2 | |
| SCHEMBL18018886 | 0.78 | TTK (0.63) | ALKTTKIGF1RINSRFGFR1 | |
| SCHEMBL3950201 | 0.76 | FES (0.66) | ALKTTKIGF1RINSRFGFR1 | |
| SCHEMBL3953378 | 0.74 | ALK (0.55) | ALKTTKIGF1RINSRFGFR1 | |
| SCHEMBL18018799 | 0.73 | TTK (0.70) | ALKTTKIGF1RINSRFGFR1 | |
| SCHEMBL3951761 | 0.72 | ALK (0.61) | ALKTTKIGF1RINSRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3778604-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |