Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 5/20 | 0.54 |
| ▸ | DCLK1 | O15075 | 3/20 | 0.52 |
| ▸ | MAPK7 | Q13164 | 3/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.52 |
| ▸ | FES | P07332 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.47 |
| ▸ | IGF1R | P08069 | 6/20 | 0.47 |
| ▸ | INSR | P06213 | 4/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22985929 | 0.93 | TTK (0.57) | TTKDCLK1MAPK7LRRK2FES | |
| SCHEMBL22985875 | 0.92 | TTK (0.51) | TTKDCLK1MAPK7LRRK2FES | |
| SCHEMBL22985895 | 0.90 | ALK (0.45) | TTKDCLK1MAPK7LRRK2FES | |
| SCHEMBL18018886 | 0.88 | TTK (0.63) | TTKDCLK1MAPK7LRRK2FES | |
| SCHEMBL22985880 | 0.83 | ALK (0.63) | LRRK2FESFLT3PLK1ALK | |
| SCHEMBL18018796 | 0.81 | TTK (0.80) | TTKDCLK1MAPK7LRRK2FES | |
| SCHEMBL18018865 | 0.80 | TTK (0.68) | TTKDCLK1MAPK7LRRK2FES | |
| SCHEMBL18018799 | 0.79 | TTK (0.70) | TTKDCLK1MAPK7LRRK2FES | |
| SCHEMBL18018899 | 0.78 | ALK (0.53) | TTKDCLK1MAPK7LRRK2FES | |
| SCHEMBL21100183 | 0.76 | ALK (0.56) | TTKDCLK1MAPK7LRRK2FES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3778604-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |