Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.36 |
| ▸ | LIPE | Q05469 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34474589 | 0.84 | NR1H2 (0.48) | NR1H2DDB1CRBNNAMPTUSP2 | |
| SCHEMBL23924565 | 0.80 | NR1H2 (0.45) | NR1H2DDB1CRBNNAMPTRORC | |
| SCHEMBL24161826 | 0.79 | NR1H2 (0.51) | NR1H2DDB1CRBNNAMPTUSP2 | |
| SCHEMBL14697592 | 0.77 | NR1H2 (0.50) | NR1H2DDB1CRBNNAMPTUSP2 | |
| SCHEMBL13567936 | 0.77 | NR1H2 (0.41) | NR1H2DDB1CRBNNAMPTRORC | |
| SCHEMBL34474666 | 0.75 | NR1H2 (0.46) | NR1H2DDB1CRBNNAMPTUSP2 | |
| SCHEMBL24220752 | 0.75 | MEN1 (0.45) | TACR1GPR119USP30MEN1ALDH1A1 | |
| SCHEMBL22989925 | 0.74 | NR1H2 (0.44) | NR1H2DDB1CRBNNAMPTRORC | |
| SCHEMBL28673765 | 0.74 | NR1H2 (0.44) | NR1H2DDB1CRBNGPR119MEN1 | |
| SCHEMBL21101366 | 0.74 | NR1D1 (0.40) | NR1H2GPR119USP30MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021027943-A1 | PYRIMIDINOPYRIDAZINONE DERIVATIVE AND MEDICAL USE THEREOF | 正大天晴药业集团南京顺欣制药有限公司 | 2021-02-18 | — | — | WO | disclosed |