SCHEMBL22990611

Nc1ncnc2c1ncn2[C@H]1CC[C@@](CO)(COP(=O)(O)O[C@]2(Cn3cc(F)c4c(=O)[nH]cnc43)CO[C@H](COP(=O)(O)S)C2)O1

nearest known ligand 0.34

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	DTYMK	P23919	4/20	0.34

▸	ENPP1	P22413	2/20	0.33

▸	P2RX1	P51575	1/20	0.33

▸	P2RX3	P56373	1/20	0.33

▸	P2RX4	Q99571	1/20	0.33

▸	P2RY1	P47900	4/20	0.32

▸	P2RY2	P41231	2/20	0.32

▸	P2RY11	Q96G91	1/20	0.32

▸	POLB	P06746	1/20	0.32

▸	ADORA3	P0DMS8	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL20224913	0.82	DTYMK (0.38)	DTYMKP2RX1P2RX3P2RX4
SCHEMBL20224825	0.78	DTYMK (0.40)	DTYMKP2RY1P2RY2P2RY11
SCHEMBL20224826	0.77	DNPH1 (0.39)	DTYMKP2RY1P2RY2P2RY11POLB
SCHEMBL20224911	0.74	RNASEL (0.55)	—
SCHEMBL20224880	0.74	DTYMK (0.38)	DTYMKP2RX1P2RX3P2RX4
SCHEMBL22990449	0.71	P2RY1 (0.54)	ENPP1P2RY1P2RY2P2RY11POLB
SCHEMBL22990408	0.69	POLB (0.43)	DTYMKENPP1P2RY1P2RY2P2RY11
SCHEMBL20324651	0.68	TAS1R3 (0.47)	ENPP1P2RY1POLBADORA3
SCHEMBL20224827	0.68	RNASEL (0.53)	—
SCHEMBL20324545	0.68	STING1 (0.39)	POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-3512861-B1	CYCLIC DINUCLEOTIDES AS STING (STIMULATOR OF INTERFERON GENES) AGONISTS	TAKEDA PHARMACEUTICALS CO (JP)	2021-02-17	—	—	EP	disclosed