Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 7/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21292583 | 0.79 | ACHE (0.64) | ADORA1ADORA2AACHEBCHEKDR | |
| SCHEMBL28107490 | 0.70 | KDM4E (0.42) | MAPTMEN1KMT2ASQORKDM4E | |
| SCHEMBL27409414 | 0.69 | KDR (0.54) | ADORA1ADORA2AACHEBCHEKDR | |
| SCHEMBL14523463 | 0.67 | LMNA (0.73) | ADORA1ADORA2AACHEBCHEMAPT | |
| SCHEMBL29672082 | 0.67 | LMNA (0.50) | ADORA1MAPTLMNAMEN1KMT2A | |
| SCHEMBL13273646 | 0.67 | ADORA2A (0.54) | ADORA1ADORA2AACHEBCHEMAPT | |
| SCHEMBL10146681 | 0.66 | ADORA2A (0.52) | ADORA1ADORA2AACHEMAPTHPGD | |
| SCHEMBL25473538 | 0.66 | ADORA1 (0.49) | ADORA1ADORA2AACHEBCHEMAPT | |
| SCHEMBL26153067 | 0.66 | ADORA1 (0.49) | ADORA1ADORA2AACHEBCHEMAPT | |
| SCHEMBL18416147 | 0.66 | ACHE (0.55) | ADORA1ADORA2AACHEBCHEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003597-B2 | Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level | ARENA PHARMACEUTICALS, INC. (US) | 2011-08-23 | — | — | US | disclosed |