Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | DRD1 | P21728 | 4/20 | 0.41 |
| ▸ | DRD5 | P21918 | 4/20 | 0.41 |
| ▸ | DRD3 | P35462 | 4/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22993443 | 0.86 | MAOA (0.46) | MAOAMAOBDRD2DRD1DRD5 | |
| SCHEMBL24253322 | 0.78 | MAOA (0.42) | MAOAMAOBDRD2DRD1DRD5 | |
| SCHEMBL24253472 | 0.76 | MAOA (0.40) | MAOAMAOBDRD2DRD1DRD5 | |
| SCHEMBL7957052 | 0.74 | MAOA (0.59) | MAOAMAOBDRD2DRD1DRD5 | |
| SCHEMBL24913963 | 0.74 | MAOA (0.44) | MAOAMAOBDRD2DRD1DRD5 | |
| SCHEMBL17462479 | 0.73 | ADRA2A (0.48) | MAOAMAOBDRD2DRD1DRD5 | |
| SCHEMBL12363777 | 0.73 | MAOA (0.57) | MAOAMAOBDRD2DRD1DRD5 | |
| SCHEMBL22993136 | 0.73 | SLC6A2 (0.38) | MAOAMAOBDRD2DRD1DRD5 | |
| SCHEMBL24556384 | 0.72 | CES1 (0.41) | DRD4 | |
| SCHEMBL20244672 | 0.72 | CES1 (0.37) | DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021028645-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021028649-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |