Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.49 |
| ▸ | DRD3 | P35462 | 6/20 | 0.49 |
| ▸ | DRD4 | P21917 | 4/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2301417 | 0.86 | DRD2 (0.47) | DRD2DRD3DRD4CHRM2CHRM1 | |
| SCHEMBL6233003 | 0.83 | DRD2 (0.45) | DRD2DRD3DRD4CHRM2CHRM1 | |
| SCHEMBL2298646 | 0.81 | TIPARP (0.41) | DRD2DRD3ADRA2ACYP19A1 | |
| SCHEMBL9404768 | 0.79 | MAPK1 (0.40) | DRD2DRD1 | |
| SCHEMBL2299356 | 0.78 | CCR3 (0.33) | — | |
| SCHEMBL3250725 | 0.78 | NPC1 (0.32) | — | |
| SCHEMBL9404907 | 0.77 | KDM4E (0.44) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL7305300 | 0.77 | ADRA1A (0.43) | — | |
| SCHEMBL19133719 | 0.77 | DRD2 (0.58) | DRD2DRD3DRD4CHRM2CHRM1 | |
| SCHEMBL31121182 | 0.76 | DRD2 (0.46) | DRD2DRD3DRD4CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| EP-2536689-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | Amgen Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103196-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | AMGEN INC. (US) | 2011-08-25 | — | — | WO | disclosed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | disclosed |
| EP-0645390-A1 | Trisubstituted pyrimido 5,4-d pyrimidines for modulating multidrug resistance, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1995-03-29 | — | — | EP | disclosed |
| EP-0313081-B1 | 2-Oxa-isocephem compounds, compositions containing the same and processes for preparing the same | OTSUKA PHARMA CO LTD (JP) | 1994-02-02 | — | — | EP | disclosed |
| US-4950662-A | ANTIBIOTIC | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-21 | — | — | US | disclosed |
| EP-0313081-A2 | 2-Oxa-isocephem compounds, compositions containing the same and processes for preparing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-26 | — | — | EP | disclosed |