Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2301417 | 0.77 | DRD2 (0.47) | — | |
| SCHEMBL2299447 | 0.77 | DRD2 (0.49) | — | |
| SCHEMBL9404766 | 0.76 | KDM4E (0.44) | KDM4EALDH1A1HPGDACHEHTR2C | |
| SCHEMBL9404907 | 0.76 | KDM4E (0.44) | KDM4EALDH1A1HPGDACHE | |
| SCHEMBL833885 | 0.72 | ADRA1A (0.59) | ADRA1AKDM4EALDH1A1HPGDGLA | |
| SCHEMBL10969055 | 0.72 | ADRA1A (0.59) | ADRA1AKDM4EALDH1A1HPGDGLA | |
| SCHEMBL9573096 | 0.68 | HTR2C (0.45) | ADRA1AKDM4EALDH1A1HPGDGLA | |
| SCHEMBL5143947 | 0.67 | KDM4E (0.61) | ADRA1AKDM4EALDH1A1HPGDGLA | |
| SCHEMBL18183438 | 0.67 | MAOA (0.51) | ADRA1AKDM4EALDH1A1HPGDGLA | |
| SCHEMBL443555 | 0.67 | MAOA (0.50) | KDM4EALDH1A1GLAGAAHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0614893-B1 | Benzoxazine derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1998-05-27 | — | — | EP | claimed |
| EP-0666250-B1 | Derivatives of N-(3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide having neuroprotective and anti-ischemic properties, their preparation and their use, in therapy | SYNTHELABO (FR) | 1998-02-11 | — | — | EP | claimed |
| US-5663183-A | CEREBRAL DISORDERS | SYNTHELABO (FR) | 1997-09-02 | — | — | US | claimed |
| US-5447928-A | Antiischemic agents and nervous system disorders | SYNTHELABO (FR) | 1995-09-05 | — | — | US | claimed |
| US-5663183-A | CEREBRAL DISORDERS | SYNTHELABO (FR) | 1997-09-02 | — | — | US | disclosed |
| US-5663183-A | CEREBRAL DISORDERS | SYNTHELABO (FR) | 1997-09-02 | — | — | US | disclosed |
| US-5550162-A | TREATMENT AND PREVENTION OF CEREBRAL DISORDERS | SYNTHELABO (FR) | 1996-08-27 | — | — | US | disclosed |
| US-5550162-A | TREATMENT AND PREVENTION OF CEREBRAL DISORDERS | SYNTHELABO (FR) | 1996-08-27 | — | — | US | disclosed |
| US-5447928-A | Antiischemic agents and nervous system disorders | SYNTHELABO (FR) | 1995-09-05 | — | — | US | disclosed |
| US-5447928-A | Antiischemic agents and nervous system disorders | SYNTHELABO (FR) | 1995-09-05 | — | — | US | disclosed |
| EP-0666250-A1 | Derivatives of N-(3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide having neuroprotective and anti-ischemic properties, their preparation and their use, in therapy | SYNTHELABO (FR) | 1995-08-09 | — | — | EP | disclosed |
| EP-0614893-A1 | Benzoazine derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1994-09-14 | — | — | EP | disclosed |