Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HSPA9 | P38646 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTR1E | P28566 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6219295 | 0.78 | L3MBTL1 (0.40) | KMT2AMEN1MAPK1NPC1RAB9A | |
| SCHEMBL14311949 | 0.76 | BACE1 (0.43) | MAPTALDH1A1GAA | |
| SCHEMBL2719847 | 0.66 | NAMPT (0.80) | MAPTKMT2AMEN1NPSR1MAPK1 | |
| SCHEMBL2302824 | 0.66 | KMT2A (0.40) | MAPTKMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL2355515 | 0.66 | LMNA (0.42) | MAPTKMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL14505991 | 0.64 | NAMPT (0.71) | MAPTKMT2AMEN1NPSR1MAPK1 | |
| SCHEMBL14637459 | 0.64 | MAPT (0.53) | MAPTKMT2AMEN1NPSR1MAPK1 | |
| SCHEMBL18040074 | 0.64 | NAMPT (1.00) | MAPTKMT2AMEN1NPSR1MAPK1 | |
| SCHEMBL8520214 | 0.62 | NAMPT (0.62) | MAPTKMT2AMEN1NPSR1MAPK1 | |
| SCHEMBL5912219 | 0.62 | NAMPT (0.58) | MAPTKMT2AMEN1NPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101297-A1 | SUBSTITUTED SPIROINDOLINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-25 | — | — | WO | claimed |