Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 13/20 | 0.63 |
| ▸ | MTHFD1 | P11586 | 1/20 | 0.63 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.63 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.49 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.46 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.46 |
| ▸ | GART | P22102 | 1/20 | 0.46 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.46 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23005176 | 1.00 | FPR2 (0.63) | FPR2MTHFD1MTHFD2FOLH1FOLR2 | |
| SCHEMBL21494665 | 0.88 | FPR2 (0.64) | FPR2MTHFD1MTHFD2FOLH1GART | |
| SCHEMBL21494667 | 0.88 | FPR2 (0.64) | FPR2MTHFD1MTHFD2FOLH1GART | |
| SCHEMBL23005252 | 0.87 | FPR2 (0.63) | FPR2MTHFD1MTHFD2FOLH1KDM4E | |
| SCHEMBL23005249 | 0.87 | FPR2 (0.63) | FPR2MTHFD1MTHFD2FOLH1KDM4E | |
| SCHEMBL23005142 | 0.86 | FPR2 (0.65) | FPR2MTHFD1MTHFD2FOLH1KDM4E | |
| SCHEMBL23005143 | 0.86 | FPR2 (0.65) | FPR2MTHFD1MTHFD2FOLH1KDM4E | |
| SCHEMBL23005246 | 0.81 | FPR2 (0.56) | FPR2MTHFD1MTHFD2FOLH1FOLR2 | |
| SCHEMBL23005243 | 0.81 | FPR2 (0.56) | FPR2MTHFD1MTHFD2FOLH1FOLR2 | |
| SCHEMBL21515060 | 0.80 | L3MBTL1 (0.48) | FPR2MTHFD1MTHFD2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112218858-B | 2, 6-Diamino-3, 4-dihydropyrimidin-4-one derivatives and their use in therapy | 托马斯·黑勒戴药物研究基金会 | 2024-06-18 | — | — | CN | disclosed |
| EP-3781554-B1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | THOMAS HELLEDAYS STIFTELSE FOER MEDICINSK FORSKNING (SE) | 2023-06-28 | — | — | EP | disclosed |
| US-20210052587-A1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | MEDICINSK FORSKNING (SE) | 2021-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210052587-A1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | IL2, THPO, IL6 | FPR2 435/4885MTHFD1 2241/4885MTHFD2 478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.