Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 4/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 6/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2354750 | 0.80 | ABHD6 (0.54) | ABHD6SCN9ASSTR4S1PR5ACKR3 | |
| SCHEMBL7743587 | 0.79 | ABHD6 (0.55) | ABHD6S1PR5ACACBCARM1 | |
| SCHEMBL2355835 | 0.77 | ABHD6 (0.55) | ABHD6SCN9AACACB | |
| SCHEMBL7737943 | 0.71 | CARM1 (0.39) | ABHD6S1PR5ARCARM1 | |
| SCHEMBL15335809 | 0.70 | RXRA (0.49) | SSTR4ADRA2AADRA2BADRA2C | |
| Trifluoroacetic Acid SCHEMBL2355342 | 0.69 | P2RY1 (0.43) | SCN9ASSTR4S1PR5HRH3 | |
| SCHEMBL7744238 | 0.69 | NR1H3 (0.36) | ABHD6S1PR5 | |
| SCHEMBL7744239 | 0.69 | NR1H3 (0.36) | ABHD6S1PR5 | |
| SCHEMBL14961675 | 0.65 | CD44 (0.47) | HRH3 | |
| SCHEMBL2301748 | 0.65 | SCN9A (0.36) | ABHD6SCN9ASSTR4S1PR5ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536689-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | Amgen Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103196-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | AMGEN INC. (US) | 2011-08-25 | — | — | WO | disclosed |