Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 9/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 5/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2300549 | 0.79 | ABHD6 (0.47) | ABHD6CARM1ACACBS1PR5 | |
| SCHEMBL7738243 | 0.77 | ABHD6 (0.54) | ABHD6AKR1C3CARM1 | |
| SCHEMBL772680 | 0.77 | ABHD6 (0.69) | ABHD6AKR1C3CARM1PRMT6PRMT1 | |
| SCHEMBL7737943 | 0.73 | CARM1 (0.39) | ABHD6CARM1S1PR5 | |
| SCHEMBL7744239 | 0.73 | NR1H3 (0.36) | ABHD6S1PR5 | |
| SCHEMBL7744238 | 0.73 | NR1H3 (0.36) | ABHD6S1PR5 | |
| SCHEMBL29163080 | 0.73 | ABHD6 (0.36) | ABHD6UCHL1 | |
| SCHEMBL3716227 | 0.72 | TRPM8 (0.56) | ABHD6 | |
| SCHEMBL2119725 | 0.71 | ABHD6 (0.65) | ABHD6UCHL1 | |
| SCHEMBL29421744 | 0.71 | ABHD6 (0.65) | ABHD6UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |