Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23006350 | 0.85 | GPR119 (0.35) | GPR119USP30CYP19A1KDM4EPKM | |
| SCHEMBL23006359 | 0.84 | GPR119 (0.39) | GPR119USP30CYP19A1KDM4EPKM | |
| SCHEMBL29862409 | 0.84 | GPR119 (0.39) | GPR119USP30CYP19A1KDM4EPKM | |
| SCHEMBL23006678 | 0.83 | TGFBR1 (0.33) | GPR119USP30CYP19A1KDM4EPKM | |
| SCHEMBL23006686 | 0.83 | GPR119 (0.33) | GPR119USP30CYP19A1KDM4EPKM | |
| SCHEMBL23006917 | 0.78 | GPR119 (0.35) | GPR119USP30KDM4EPKMNAMPT | |
| SCHEMBL23006358 | 0.77 | SMN1; SMN2 (0.41) | GPR119USP30KDM4EKDR | |
| SCHEMBL23006360 | 0.76 | GPR119 (0.41) | GPR119USP30KDM4EPKMNAMPT | |
| SCHEMBL23006911 | 0.76 | GPR119 (0.40) | GPR119USP30KDM4EPKMNAMPT | |
| SCHEMBL23005931 | 0.76 | GPR119 (0.40) | GPR119USP30KDM4EPKMNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021030556-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-02-18 | — | — | WO | disclosed |