Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29862409 | 1.00 | GPR119 (0.39) | GPR119CYP19A1USP30CNR1CNR2 | |
| SCHEMBL22982348 | 0.88 | CHRM3 (0.36) | CYP19A1CNR1CNR2KDM4E | |
| SCHEMBL23006351 | 0.84 | GPR119 (0.37) | GPR119CYP19A1USP30CNR1CNR2 | |
| SCHEMBL23006350 | 0.82 | GPR119 (0.35) | GPR119CYP19A1USP30CNR1CNR2 | |
| SCHEMBL29862313 | 0.81 | GPR119 (0.40) | GPR119USP30ADORA2AADORA2BGRM5 | |
| SCHEMBL23006911 | 0.81 | GPR119 (0.40) | GPR119USP30ADORA2AADORA2BGRM5 | |
| SCHEMBL23005931 | 0.81 | GPR119 (0.40) | GPR119USP30ADORA2AADORA2BGRM5 | |
| SCHEMBL23006358 | 0.81 | SMN1; SMN2 (0.41) | GPR119USP30KDM4E | |
| SCHEMBL23006360 | 0.80 | GPR119 (0.41) | GPR119USP30ADORA2AADORA2BGRM5 | |
| SCHEMBL23006678 | 0.80 | TGFBR1 (0.33) | GPR119CYP19A1USP30CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114585628-B | Modulators of cystic fibrosis transmembrane conductance regulator | 弗特克斯药品有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-114585628-A | Modulators of cystic fibrosis transmembrane conductance regulator | 弗特克斯药品有限公司 | 2022-06-03 | — | — | CN | disclosed |
| WO-2021030556-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-02-18 | — | — | WO | disclosed |