Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2302451 | 0.79 | MEN1 (0.31) | — | |
| SCHEMBL2296573 | 0.78 | — | — | |
| SCHEMBL2297989 | 0.77 | — | — | |
| SCHEMBL2299233 | 0.75 | — | — | |
| SCHEMBL2299850 | 0.73 | — | — | |
| SCHEMBL2297096 | 0.70 | ATM (0.37) | ALDH1A1 | |
| SCHEMBL2301661 | 0.69 | LMNA (0.32) | KDM4E | |
| SCHEMBL2299639 | 0.69 | — | — | |
| SCHEMBL2297156 | 0.66 | CTSK (0.32) | — | |
| SCHEMBL13635253 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999006-B2 | Anticancer agents; mitogen-activated protein kinases (MEK) | EXELIXIS, INC. (US) | 2011-08-16 | — | — | US | claimed |