SCHEMBL230136

SCHEMBL230136

CN(c1ccc(Cl)cc1)c1ccc(C(=O)c2cc(C(=O)O)cc(N(C)c3ccccc3)c2)cc1

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 3/20 0.51
LMNA P02545 2/20 0.51
L3MBTL1 Q9Y468 2/20 0.51
NPC1 O15118 1/20 0.47
HPGD P15428 1/20 0.47
RAB9A P51151 1/20 0.47
NR4A1 P22736 1/20 0.45
LTC4S Q16873 11/20 0.44
ALOX15 P16050 1/20 0.43
TSHR P16473 1/20 0.43
RXRA P19793 1/20 0.43
NR4A2 P43354 1/20 0.43
ALDH1A1 P00352 1/20 0.43
HTT P42858 1/20 0.43
NOD2 Q9HC29 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL232237 0.96 SRD5A2 (0.56) SRD5A2LMNAL3MBTL1NPC1HPGD
SCHEMBL2743193 0.89 LMNA (0.44) SRD5A2LMNAL3MBTL1NPC1HPGD
SCHEMBL2743197 0.88 LTC4S (0.43) SRD5A2LMNAL3MBTL1NPC1HPGD
SCHEMBL232232 0.87 LMNA (0.50) SRD5A2LMNAL3MBTL1NPC1HPGD
SCHEMBL2743205 0.86 LMNA (0.42) SRD5A2LMNAL3MBTL1NPC1HPGD
SCHEMBL2743209 0.86 LMNA (0.46) SRD5A2LMNAL3MBTL1NPC1HPGD
SCHEMBL2743187 0.86 SRD5A2 (0.47) SRD5A2LMNAL3MBTL1LTC4SALOX15
SCHEMBL233238 0.86 SRD5A2 (0.51) SRD5A2LMNAL3MBTL1NPC1HPGD
SCHEMBL2743185 0.86 MAPK13 (0.47) SRD5A2LMNAL3MBTL1NPC1HPGD
SCHEMBL231992 0.85 FFAR1 (0.50) SRD5A2LMNAL3MBTL1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120004228-A1 Bis Aromatic Compounds for Use as LTC4 Synthase Inhibitors BIOLIPOX AB (SW) 2012-01-05 US disclosed
US-20120004228-A1 Bis Aromatic Compounds for Use as LTC4 Synthase Inhibitors BIOLIPOX AB (SW) 2012-01-05 US disclosed
US-20120004228-A1 Bis Aromatic Compounds for Use as LTC4 Synthase Inhibitors BIOLIPOX AB (SW) 2012-01-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120004228-A1 Bis Aromatic Compounds for Use as LTC4 Synthase Inhibitors LTC4S, LTB4R2, LTB4R SRD5A2 564/4885LMNA 1141/4885L3MBTL1 324/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.