Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 6/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ACLY | P53396 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2298742 | 0.80 | SLC6A4 (0.57) | SLC6A4SLC6A2SLC6A3LMNASMN1; SMN2 | |
| SCHEMBL2302743 | 0.78 | SLC6A4 (0.52) | SLC6A4SLC6A2SLC6A3LMNAMAPT | |
| SCHEMBL14312031 | 0.74 | SLC6A4 (0.58) | SLC6A4SLC6A2SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL2300977 | 0.74 | SLC6A4 (0.62) | SLC6A4SLC6A2SLC6A3TSHRTP53 | |
| SCHEMBL7726520 | 0.71 | HRH1 (0.55) | SLC6A4SLC6A2SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL19083886 | 0.71 | SLC6A4 (0.41) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2300752 | 0.70 | SLC6A4 (0.45) | SLC6A4SLC6A2SLC6A3CYP3A4CYP2C9 | |
| SCHEMBL2297174 | 0.69 | FPR2 (0.44) | SLC6A4SLC6A2SLC6A3LMNAMAPT | |
| SCHEMBL2296925 | 0.69 | GRIN1 (0.39) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2301256 | 0.68 | HRH1 (0.52) | SLC6A4SLC6A2SLC6A3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536689-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | Amgen Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103196-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | AMGEN INC. (US) | 2011-08-25 | — | — | WO | disclosed |