Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PLTP | P55058 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2304830 | 0.93 | ALDH1A1 (0.58) | ADORA3LMNAALDH1A1KDM4EPOLB | |
| SCHEMBL2300888 | 0.91 | ADORA3 (0.62) | ADORA3LMNAALDH1A1KDM4EPOLB | |
| SCHEMBL2357114 | 0.88 | TBK1 (0.56) | ADORA3LMNAALDH1A1KDM4EPOLB | |
| SCHEMBL3310436 | 0.87 | ALDH1A1 (0.57) | ADORA3LMNAALDH1A1KDM4EPOLB | |
| SCHEMBL2302579 | 0.86 | ADORA3 (0.50) | ADORA3LMNAALDH1A1KDM4EPOLB | |
| SCHEMBL2300926 | 0.85 | ADORA3 (0.59) | ADORA3LMNAALDH1A1KDM4EPOLB | |
| SCHEMBL3309522 | 0.85 | ALDH1A1 (0.59) | ADORA3LMNAALDH1A1KDM4EPOLB | |
| SCHEMBL2363710 | 0.84 | ALDH1A1 (0.61) | ADORA3LMNAALDH1A1KDM4EPOLB | |
| SCHEMBL2303642 | 0.84 | ADORA3 (0.55) | ADORA3LMNAALDH1A1KDM4EPOLB | |
| SCHEMBL2358816 | 0.83 | ADORA3 (0.50) | ADORA3LMNAALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350311-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | Via Pharmaceuticals, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010056506-A1 | DIACYLGLYCEROL ACLYTRANSFERASE INHIBITORS | VIA PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | WO | disclosed |