Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 7/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | C5 | P01031 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL657786 | 0.99 | PRKCZ (0.49) | PRKCZRAB9AKDM4EPIN1TDP1 | |
| SCHEMBL2301512 | 0.90 | PRKCZ (0.61) | PRKCZRAB9AKDM4EPIN1TDP1 | |
| SCHEMBL659483 | 0.82 | PRKCZ (0.72) | PRKCZRAB9AKDM4EPIN1TDP1 | |
| SCHEMBL11100682 | 0.82 | PRKCZ (0.46) | PRKCZRAB9AKDM4EPIN1TDP1 | |
| Hydrochloric Acid SCHEMBL657199 | 0.81 | PRKCZ (0.71) | PRKCZRAB9AKDM4EPIN1TDP1 | |
| SCHEMBL655992 | 0.79 | PRKCZ (0.58) | PRKCZRAB9AKDM4ETDP1NPC1 | |
| SCHEMBL657366 | 0.77 | PRKCZ (0.56) | PRKCZRAB9AKDM4ETDP1NPC1 | |
| SCHEMBL2304297 | 0.77 | PRKCZ (0.68) | PRKCZRAB9AKDM4EPIN1NPC1 | |
| SCHEMBL3100859 | 0.76 | RAB9A (0.52) | PRKCZRAB9AKDM4ETDP1NPC1 | |
| SCHEMBL2303912 | 0.76 | PRKCZ (0.84) | PRKCZRAB9AKDM4EPIN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | claimed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | claimed |
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |