Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL229080 | 0.88 | ALDH1A1 (0.53) | ALDH1A1CYP2C19POLBCYP2C9SMN1; SMN2 | |
| SCHEMBL230158 | 0.83 | ALDH1A1 (0.80) | ALDH1A1CYP2C19POLBCYP2C9SMN1; SMN2 | |
| SCHEMBL728401 | 0.77 | NPC1 (0.56) | ALDH1A1CYP2C19POLBCYP2C9SMN1; SMN2 | |
| SCHEMBL2166193 | 0.74 | ALDH1A1 (0.63) | ALDH1A1CYP2C19POLBCYP2C9SMN1; SMN2 | |
| SCHEMBL6202777 | 0.72 | MAPT (0.64) | ALDH1A1SMN1; SMN2MAPTLMNAMAOB | |
| SCHEMBL727061 | 0.72 | TSHR (0.53) | ALDH1A1CYP2C19POLBCYP2C9SMN1; SMN2 | |
| SCHEMBL11933966 | 0.72 | ALDH1A1 (1.00) | ALDH1A1CYP2C19POLBCYP2C9SMN1; SMN2 | |
| SCHEMBL2163743 | 0.72 | PDPK1 (0.49) | ALDH1A1POLBMAPTLMNAHSP90AA1 | |
| SCHEMBL11022763 | 0.72 | ALDH1A1 (0.54) | ALDH1A1CYP2C19POLBCYP2C9MAPT | |
| SCHEMBL728190 | 0.71 | ALDH1A1 (0.70) | ALDH1A1POLBMAPTHTTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329149-B2 | Topical lightening composition and uses thereof | AVON PRODUCTS, INC. (US) | 2012-12-11 | — | — | US | claimed |
| EP-2521558-A1 | TOPICAL LIGHTENING COMPOSITION AND USES THEREOF | Avon Products, Inc. (US) | 2012-11-14 | — | — | EP | claimed |
| US-20120003168-A1 | Topical Lightening Composition and Uses Thereof | AVON PRODUCTS, INC. (US) | 2012-01-05 | — | — | US | claimed |
| WO-2011082044-A1 | TOPICAL LIGHTENING COMPOSITION AND USES THEREOF | AVON PRODUCTS, INC. (US) | 2011-07-07 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120003168-A1 | Topical Lightening Composition and Uses Thereof | TYR, AOC3, TH | ALDH1A1 129/4885CYP2C19 1250/4885POLB 232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.