Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 4/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2302824 | 0.89 | KMT2A (0.40) | ACHEBCHEPOLBMAPTALDH1A1 | |
| SCHEMBL14311949 | 0.81 | BACE1 (0.43) | ACHEBCHEBACE1MAPTKDM1A | |
| SCHEMBL28998851 | 0.68 | BACE1 (0.43) | BACE1KDM1A | |
| SCHEMBL6219295 | 0.65 | L3MBTL1 (0.40) | POLB | |
| SCHEMBL8839080 | 0.63 | RXRA (0.61) | ELANEHSD17B10RXRARXRBRXRG | |
| SCHEMBL24736421 | 0.62 | HTR2A (0.42) | HSD17B10BACE1KDM1AALDH1A1 | |
| SCHEMBL11672849 | 0.61 | SRD5A2 (0.62) | ELANESRD5A2PKMHSD17B10 | |
| SCHEMBL12891019 | 0.60 | KDM1A (0.46) | BACE1KDM1AALDH1A1 | |
| SCHEMBL28453797 | 0.60 | KDM1A (0.36) | POLBBACE1KDM1AALDH1A1 | |
| SCHEMBL1756160 | 0.60 | KMT2A (0.54) | ELANESRD5A2POLBHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536731-A1 | SUBSTITUTED SPIROINDOLINONES | F. Hoffmann-La Roche AG (CH) | 2012-12-26 | — | — | EP | claimed |
| WO-2011101297-A1 | SUBSTITUTED SPIROINDOLINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-25 | — | — | WO | claimed |