SCHEMBL28453797

SCHEMBL28453797

O=CC1Nc2ccccc2C12CNC2

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 1/20 0.36
BACE1 P56817 1/20 0.35
ALDH1A1 P00352 2/20 0.33
MEN1 O00255 1/20 0.33
POLB P06746 1/20 0.33
KMT2A Q03164 1/20 0.33
GAA P10253 1/20 0.33
MAPK1 P28482 1/20 0.33
CNR1 P21554 1/20 0.32
PTPN1 P18031 1/20 0.32
BRD4 O60885 3/20 0.31
CREBBP Q92793 3/20 0.31
EP300 Q09472 1/20 0.31
PDK2 Q15119 1/20 0.31
PDK4 Q16654 1/20 0.31
TACR1 P25103 2/20 0.30
BRPF1 P55201 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28998851 0.89 BACE1 (0.43) KDM1ABACE1
SCHEMBL26107258 0.88 KDM1A (0.44) KDM1ABACE1ALDH1A1MEN1POLB
SCHEMBL29076752 0.85 KDM1A (0.38) KDM1ABACE1ALDH1A1MEN1POLB
SCHEMBL28496380 0.83 PDE7A (0.41) KDM1AALDH1A1MEN1POLBKMT2A
SCHEMBL28467068 0.76 CYP2D6 (0.33) KDM1AALDH1A1MEN1KMT2ACNR1
SCHEMBL28904764 0.75 KDM1A (0.40) KDM1AALDH1A1
SCHEMBL23581199 0.75 PDK2 (0.40) ALDH1A1MEN1POLBKMT2AGAA
SCHEMBL28496477 0.72 KDM1A (0.32) KDM1A
SCHEMBL27421867 0.71 CREBBP (0.36) ALDH1A1MEN1KMT2AGAACNR1
SCHEMBL27449367 0.69 ALDH1A1 (0.36) ALDH1A1MEN1POLBKMT2AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107922407-B Respiratory syncytial virus inhibitors 勃林格殷格翰国际有限公司 2020-09-25 CN disclosed