Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | CES1 | P23141 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12963614 | 0.86 | TDP1 (0.45) | TDP1MAPK1ALDH1A1TSHRMAPT | |
| SCHEMBL10228486 | 0.75 | TDP1 (0.35) | TDP1MAPK1ALDH1A1TSHRMAPT | |
| SCHEMBL13825219 | 0.75 | ALDH1A1 (0.40) | TDP1MAPK1ALDH1A1LMNATRPA1 | |
| SCHEMBL19624772 | 0.75 | AKT1 (0.39) | TDP1MAPK1ALDH1A1LMNATSHR | |
| SCHEMBL30698175 | 0.75 | ALDH1A1 (0.40) | TDP1MAPK1ALDH1A1LMNATRPA1 | |
| SCHEMBL1825351 | 0.74 | ALDH1A1 (0.43) | TDP1MAPK1ALDH1A1LMNATRPA1 | |
| SCHEMBL3097579 | 0.74 | ALDH1A1 (0.43) | TDP1MAPK1ALDH1A1LMNATRPA1 | |
| SCHEMBL23969682 | 0.74 | ALDH1A1 (0.46) | TDP1MAPK1ALDH1A1TSHRMAPT | |
| SCHEMBL13066991 | 0.73 | TDP1 (0.41) | TDP1MAPK1ALDH1A1TSHRMAPT | |
| SCHEMBL21659115 | 0.73 | MTNR1A (0.44) | TDP1MAPK1ALDH1A1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3277677-B1 | 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS | MISSION THERAPEUTICS LTD (GB) | 2021-02-24 | — | — | EP | disclosed |