Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CCND3 | P30281 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | CCNH | P51946 | 1/20 | 0.45 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.41 |
| ▸ | SORD | Q00796 | 7/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL394023 | 0.78 | HRH3 (0.58) | CCNT1CDK4CCND1CCND3CDK7 | |
| SCHEMBL21549829 | 0.77 | IDH1 (0.47) | SORDIDH1MKNK1MKNK2 | |
| SCHEMBL2190695 | 0.76 | CCNT1 (0.44) | CCNT1CDK4CCND1CCND3CDK7 | |
| SCHEMBL17600999 | 0.76 | IDH1 (0.45) | CCNT1CDK4CCND1CCND3CDK7 | |
| SCHEMBL12594227 | 0.76 | NOS3 (0.45) | CCNT1CDK4CCND1CCND3CDK7 | |
| SCHEMBL11919248 | 0.75 | HRH3 (0.59) | SORDHRH3CYP1A2CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL6978271 | 0.74 | HRH3 (0.58) | SORDHRH3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL20098856 | 0.72 | SORD (0.59) | SORDHRH3 | |
| SCHEMBL15121155 | 0.71 | SORD (0.57) | SORDHRH3 | |
| SCHEMBL20909899 | 0.70 | ALOX5 (0.61) | MAP3K5CCNCCDK8CRHR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3434674-B1 | ((4-(2-OXOIMIDAZOLIDINE-1-YL)PYRIMIDIN-2-YL)AMINE DERIVATIVES AS MUTANT IDH INHIBITORS FOR TREATING CANCER | SHANGHAI HAIHE PHARMACEUTICAL CO LTD (CN) | 2021-02-24 | — | — | EP | disclosed |