Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23021681 | 0.88 | CHRNB2 (0.47) | CHRNB2CHRNA4GPR119AXLTYRO3 | |
| SCHEMBL23021685 | 0.81 | IKBKB (0.55) | CHRNB2CHRNA4IKBKBCHUK | |
| Hydrochloric Acid SCHEMBL70622 | 0.79 | IKBKB (0.53) | CHRNB2CHRNA4IKBKBCHUK | |
| SCHEMBL15779034 | 0.77 | ATR (0.43) | SYKKAT2BBAZ2BLRRK2PIK3CA | |
| SCHEMBL29507205 | 0.77 | KAT2B (0.39) | SYKKAT2BBAZ2BLRRK2PIM1 | |
| SCHEMBL23022126 | 0.77 | KAT2B (0.39) | SYKKAT2BBAZ2BLRRK2PIM1 | |
| SCHEMBL12180578 | 0.76 | KAT2B (0.56) | SYKKAT2BBAZ2BPDE4DPDE4A | |
| SCHEMBL23022184 | 0.76 | KAT2B (0.50) | KAT2BBAZ2BLRRK2PIM1PIM3 | |
| SCHEMBL25584602 | 0.74 | IKBKB (0.40) | CHRNB2CHRNA4OPRL1GPR119IKBKB | |
| SCHEMBL29435759 | 0.72 | LRRK2 (0.48) | SYKKAT2BBAZ2BLRRK2IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021032148-A1 | AMINOPYRAZINE COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-02-25 | — | — | WO | disclosed |