Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 9/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30045 | 0.79 | EPHX2 (0.57) | EPHX2ADRB2FAAH | |
| SCHEMBL9572112 | 0.79 | EPHX2 (0.57) | EPHX2ADRB2FAAH | |
| SCHEMBL9572108 | 0.79 | EPHX2 (0.57) | EPHX2ADRB2FAAH | |
| SCHEMBL3126722 | 0.79 | EPHX2 (0.46) | EPHX2ADRB2FPR2PROKR1NAAA | |
| SCHEMBL2299581 | 0.78 | SLC6A2 (0.37) | EPHX2GRIN1GRIN2B | |
| SCHEMBL2302743 | 0.78 | SLC6A4 (0.52) | EPHX2FPR2PROKR1MEN1KMT2A | |
| SCHEMBL2299147 | 0.78 | CA1 (0.48) | KDM4EMEN1KMT2A | |
| SCHEMBL3125920 | 0.78 | ACHE (0.41) | EPHX2FPR2PROKR1NAAAMEN1 | |
| SCHEMBL2301630 | 0.78 | TEAD1 (0.44) | EPHX2ADRB2FPR2PROKR1NAAA | |
| SCHEMBL2296925 | 0.78 | GRIN1 (0.39) | TRPA1GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| EP-2536689-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | Amgen Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103196-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | AMGEN INC. (US) | 2011-08-25 | — | — | WO | disclosed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |